Key result
Atrial septal aneurysm was significantly more prevalent in patients with cerebral ischaemia and normal carotid arteries compared to controls without stroke (27.7% vs 9.9%; P<0.001).
Why the study?
Is atrial septal aneurysm associated with an increased risk of cerebral ischaemic attack in patients with normal carotid arteries?
Population
606 patients enrolled between November 1990 and December 1996, including a study group of 245 patients with…
Comparison
Presence of atrial septal aneurysm evaluated by… vs Control population without stroke
Design
Case-control
Authors
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ASA associated with cerebral ischaemia via PFO in normal-carotid patients; hypothesis-generating and leaves open causal role pending prospective data.
Case-Control (n=606)
Yes
Is atrial septal aneurysm associated with an increased risk of cerebral ischaemic attack in patients with normal carotid arteries?
Absolute Event Rate: 27.7% vs 9.9%
p-value: p=<0.001
Atrial septal aneurysm is significantly more prevalent in patients with stroke and normal carotid arteries and is frequently associated with a patent foramen ovale, highlighting its role as a potential cardioembolic source.
Anna Vittoria Mattioli (2001) conducted a case-control in Cerebral ischaemia with normal carotid arteries (n=606). Atrial septal aneurysm vs. Control population without stroke was evaluated on Prevalence of atrial septal aneurysm (p=<0.001). Atrial septal aneurysm was significantly more prevalent in patients with cerebral ischaemia and normal carotid arteries compared to controls without stroke (27.7% vs 9.9%; P<0.001).
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