Persistent Nonhemolytic Hyperbilirubinemia Associated With Lipochromelike Pigment in Liver Cells: Report of Four Cases

Article1 November 1954PERSISTENT NONHEMOLYTIC HYPERBILIRUBINEMIA ASSOCIATED WITH LIPOCHROMELIKE PIGMENT IN LIVER CELLS: REPORT OF FOUR CASESHELMUTH SPRINZ, ROBERT S. NELSONHELMUTH SPRINZ, ROBERT S. NELSONAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-41-5-952 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe more frequent use of needle biopsies in the diagnosis of liver disease has led to the clarification of the pathogenesis in many known clinical conditions. It might be expected that the widespread employment of this procedure would also uncover certain histologic findings which, together with the clinical picture, could not be readily explained under previous concepts. In a total of 630 needle biopsies of the liver performed on the Medical Service of the 98th General Hospital, Munich, Germany, two instances have been noted of unusual biopsy findings which, in our experience, showed no correlation with the initial clinical evaluation...Bibliography1. Dubin IN (a) : Personal communication to the authors. (b) Johnson, F. B., and Dubin, I. N.: Excessive lipochrome pigment in liver cells in constitutional hyperbilirubinemia, Am. J. Path. 29: 585, 1953. Google Scholar2. Gray CH: The bile pigments, in Methuen's Monographs on biochemical subjects, 1953, Methuen, London. Google Scholar3. Himsworth HP: The liver and its diseases, 2nd Ed., 1950, Harvard University Press, Cambridge. Google Scholar4. DibleMcMichaelSherlock JHJSV: Pathology of acute hepatitis, Lancet 2: 402, 1943. CrossrefGoogle Scholar5. SherlockWalshe SVV: The post-hepatitis syndrome, Lancet 2: 482, 1946. CrossrefMedlineGoogle Scholar6. 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Author, Article, and Disclosure InformationAffiliations: *Received for publication March 16, 1954.From the Medical and Laboratory Services of the 98th General Hospital, Munich, Germany, and Walter Reed Army Hospital, Washington, D. C. 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BURKAFamilial Nonhemolytic Jaundice with Normal Liver Histology and Conjugated BilirubinChronic idiopathic jaundiceFamilial chronic idiopathic jaundice (Dubin-Sprinz disease), with a note on bromsulphalein metabolism in this diseaseCongenital Defects in Bilirubin Metabolism as Seen in the AdultBENIGN RECURRENT INTRAHEPATIC " OBSTRUCTIVE " JAUNDICEFamilial Nonhemolytic Jaundice with Conjugated Bilirubin in the SerumBLACK LIVER JAUNDICE DIAGNOSED BY NEEDLE BIOPSYChromatographic Separation of Different Bromsulphalein Metabolites in Urine and Bile1BENIGN FAMILIAL ICTERUS: A REPORT OF THREE CASES*S. ROSS FOX JR., M.D.The Cholecystogram in Chronic Idiopathic Jaundice.CHRONIC IDIOPATHIC JAUNDICEChronic idiopathic jaundiceJaundice Associated with Lipochrome Pigmentation of the Liver (Dubin -Johnson Syndrome)Mavero-Hepatic IcterusHepatitis und posthepatitische LebererkrankungenConstitutional non-hemolytic jaundice with "lipochrome" hepatosis (Dubin-Sprinz disease)Chronic idiopathic jaundicePersistent Nonhemolytic Hyperbilirubinemia with Unidentified Pigment in Liver Cells Report of Case Followed in PregnancyPROLONGED JAUNDICE WITH UNIDENTIFIED PIGMENT IN LIVER CELLS 1 November 1954Volume 41, Issue 5Page: 952-962KeywordsArmed forcesBiopsyCellsClinical pathologyLiverLiver diseasesMedical servicesPathogenesisResearch laboratories ePublished: 1 December 2008 Issue Published: 1 November 1954 PDF downloadLoading ...