Key result
Treatment with captopril, propranolol, or N(G)-nitro-L-arginine methyl ester altered the bilateral distribution of neuropeptidase activities in the frontal cortex of WKY and SHR rats.
Why the study?
Does treatment with vasoactive drugs alter neuropeptidase activity in the frontal cortex of Wistar-Kyoto and spontaneously hypertensive rats?
Does treatment with vasoactive drugs alter neuropeptidase activity in the frontal cortex of Wistar-Kyoto and spontaneously hypertensive rats?
Specific brain bilateral patterns of neuropeptidase activities change in spontaneously hypertensive rats and are modulated by antihypertensive or hypertensive drug treatments.
BACKGROUND AND OBJECTIVE: Hypertension can lead to mood disorders that may worsen or ameliorate depending on the type of antihypertensive prescribed. Depression is associated with modifications in basal brain asymmetry particularly that of the frontal cortex, which is involved in blood pressure control. Furthermore, different vasoactive drugs may change the brain's asymmetry in a manner that contributes to cognition status. We studied the bilateral activity of several neuropeptidases in frontal cortex as a reflect of the functional status of certain neuropeptides involved in mood. METHODS: Using arylamide derivatives as substrates, we fluorometrically analysed the activity of these enzymes in the left and right frontal cortex of control untreated Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHRs) and compared their activities with WKY or SHR treated with the antihypertensive drugs captopril (CAP) and propranolol (PRO) or with the hypertensive N (G)-nitro-L-arginine methyl ester. SBP was also measured in all WKY and SHR groups. RESULTS: Untreated WKY, WKY treated with CAP or PRO and SHR treated with CAP exhibited normotensive values of SBP. However, WKY treated with N (G)-nitro-L-arginine methyl ester as well as untreated SHR and SHR treated with PRO and N(G)-nitro-L-arginine methyl ester demonstrated hypertensive values of SBP. Changes in the bilateral distribution of neuropeptidases were depending on the strain, the enzyme analysed and the drug used. Normotensive WKY groups (WKY, CAP, PRO) revealed intrahemispheric correlations mainly in the left hemisphere. In contrast, WKY treated with N(G)-nitro-L-arginine methyl ester and SHR groups demonstrated intrahemispheric correlations mainly in the right hemisphere. Interhemispheric correlations were mostly observed in WKY as well as in SHR groups with antihypertensive treatments (CAP, PRO). CONCLUSION: Our results suggest specific brain bilateral patterns of neuropeptidase activities in WKY that change in SHR. This observation may be related to the cognitive disorders that have been described in these animals and that change under antihypertensive or hypertensive drug's treatments.
No takes yet. Share an insight, caveat, or question.
Prieto et al. (2018) studied Hypertension. Vasoactive drugs (captopril, propranolol, N(G)-nitro-L-arginine methyl ester) vs. Untreated WKY and SHR was evaluated on Bilateral activity of neuropeptidases in the frontal cortex and systolic blood pressure. Treatment with captopril, propranolol, or N(G)-nitro-L-arginine methyl ester altered the bilateral distribution of neuropeptidase activities in the frontal cortex of WKY and SHR rats.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: