Why the study?
Do kinase inhibitors (PD 098,059 and wortmannin) injected into the RVLM lower arterial pressure in spontaneously hypertensive and normotensive rats?
Population
Spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY)
Comparison
Bilateral injection of PD 098,059 and/or… vs Normotensive WKY rats and baseline responses
Design
Preclinical
Authors
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PI3K inhibition in the rostral ventrolateral medulla lowers pressure in hypertensive rats only; hypothesis-generating for human mechanisms.
Do kinase inhibitors (PD 098,059 and wortmannin) injected into the RVLM lower arterial pressure in spontaneously hypertensive and normotensive rats?
A phosphatidylinositol-3 kinase-dependent pathway in the RVLM is important in maintaining hypertension in spontaneously hypertensive rats, likely related to Ang II action.
Seyedabadi et al. (2001) studied this question.
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