Key result
Repeated immobilization stress produced a significant increase in the density of angiotensin II binding sites in the paraventricular nucleus and subfornical organ of rats.
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Indicates stress alters central angiotensin binding in rats; leaves open relevance to human cardiovascular stress responses.
We have studied the properties of angiotensin II binding sites in the paraventricular nucleus, subfornical organ and anterior pituitary lobe of rats subjected to repeated immobilization stress. This treatment produced significant increase in the density of angiotensin II binding sites in these two nuclei without any significant alteration in binding affinity. Repeated stress did not alter angiotensin II binding properties in the anterior pituitary lobe. Our results suggest that brain angiotensin binding sites may have a role in regulation of the stress response.
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Ċastrén et al. (1988) studied this question. Repeated immobilization stress was evaluated on Density of angiotensin II binding sites in the paraventricular nucleus, subfornical organ and anterior pituitary lobe. Repeated immobilization stress produced a significant increase in the density of angiotensin II binding sites in the paraventricular nucleus and subfornical organ of rats.
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