. Immunostaining further showed reduced signals of MKX, COL1A1 and DCN. Adjacent muscle morphology and transcriptomes were unaltered, supporting the tendon-selective nature of the observed phenotype. Together, these findings suggest that PIEZO1 contributes to collagen fibril architecture and tendon-associated transcriptional programs in female mouse Achilles tendons under baseline physiological conditions.
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Nakamichi et al. (2026) studied this question.
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