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In Brief Women differ from men with regard to muscle and tendon, most likely because of sex differences in estrogen. The present experimental findings suggest the hypothesis that estrogen has an anabolic effect on muscle primarily by lowering the protein turnover and enhancing sensitivity to resistance training. Furthermore, estrogen may reduce the stiffness of tendons, an effect that may be modified by physical training. We discuss the extent to which estrogen modulates skeletal muscle protein turnover at rest and after training.
Hansen et al. (Sat,) studied this question.