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October 1, 2001Journal of Clinical Investigation

Central melanocortin receptors regulate insulin action

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Authors

SOSilvana ObiciStony Brook UniversityZFZhaohui FengRutgers, The State University of New JerseyJTJianzhen TanAlbert Einstein College of Medicine

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Implication

Randomized trial investigates effects of melanocortin receptors on insulin action in rats, suggesting a key regulatory mechanism for energy balance.

Key Points

  • To explore how melanocortin receptors affect insulin action and body fat distribution.
  • Conscious rats received week-long infusions of α-MSH or SHU9119 in the third cerebral ventricle.
  • Food intake was kept constant across experimental groups.
  • Effects on insulin's role in glucose uptake and fat distribution were assessed.
  • α-MSH decreased intra-abdominal fat and enhanced insulin's action on glucose uptake.
  • SHU9119 increased fat accumulation and reduced insulin sensitivity.
  • These findings indicate a neuroendocrine network's role in regulating energy intake and insulin action.

Cite This Study

Obici et al. (2001) studied this question.

synapsesocial.com/papers/6a65256f6cc2d5eefe0e71a4https://doi.org/10.1172/jci200112954
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