Key result
Low serum concentrations of caveolin-2 (≤ 0.43 ng/mL) significantly increased the risk of hemorrhagic transformation after rt-PA administration in patients with acute ischemic stroke (OR 2.759).
Why the study?
Hemorrhagic transformation after intravenous thrombolysis increases mortality in ischemic stroke patients, making the identification of new clinical biomarkers of great importance.
Do serum levels of caveolin-1 and caveolin-2 predict hemorrhagic transformation in patients with acute ischemic stroke treated with rt-PA?
Observational (n=306)
Blinded analysis
No
Do serum levels of caveolin-1 and caveolin-2 predict hemorrhagic transformation in patients with acute ischemic stroke treated with rt-PA?
Odds Ratio: 2.759 (95% CI 1.685–4.462)
p-value: p=0.005
Low serum levels of caveolin-1 and caveolin-2 are independent predictors of hemorrhagic transformation in patients with acute ischemic stroke undergoing rt-PA thrombolysis.
No takes yet. Share an insight, caveat, or question.
May aid HT risk stratification post-IVT; leaves open whether biomarkers improve outcomes in prospective validation.
Sun et al. (2020) conducted an observational in Acute ischemic stroke (n=306). Low serum caveolin-2 (≤ 0.43 ng/mL) vs. Higher serum caveolin-2 (> 0.43 ng/mL) was evaluated on Hemorrhagic transformation (HT) after rt-PA administration (OR 2.759, 95% CI 1.685-4.462, p=0.005). Low serum concentrations of caveolin-2 (≤ 0.43 ng/mL) significantly increased the risk of hemorrhagic transformation after rt-PA administration in patients with acute ischemic stroke (OR 2.759).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: