Key result
Apoe -/- mice fed a high cholesterol diet post-stenting developed lesions with prominent lipid cores and elevated macrophage content, replicating human in-stent neoatherosclerosis.
Why the study?
No preclinical small animal models exist to fully elucidate the biology of in-stent neoatherosclerosis and test future treatments.
Population
Apoe -/- mice (n=6-8/group)
Comparison
High cholesterol diet vs chow after stent implantation
Design
Preclinical animal model study
Follow-up
7- or 28-days post-surgery
Authors
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Supports preclinical neoatherosclerosis research; leaves open human translation pending validation.
This study establishes the first murine model of in-stent neoatherosclerosis, providing a new platform for discovering mechanistic targets and preventative therapies.
Liu et al. (2025) studied In-stent neoatherosclerosis. High cholesterol diet (HCD) vs. Chow diet was evaluated on Development of in-stent neoatherosclerosis characteristics (plaque burden and instability). Apoe -/- mice fed a high cholesterol diet post-stenting developed lesions with prominent lipid cores and elevated macrophage content, replicating human in-stent neoatherosclerosis.
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