Key result
Wider inter-strut distance was strongly associated with drug-eluting stent restenosis (OR 17.4, P=0.04), and medial tear length predicted stent occlusion (OR 5.1, P=0.03) in an autopsy registry.
Why the study?
What are the histomorphological predictors and neointimal characteristics of drug-eluting stent restenosis compared to bare metal stents?
Population
82 patients with drug-eluting stent (DES) implants from an autopsy registry
Comparison
Drug-eluting stents vs Bare metal stents for neointimal characteristics…
Design
Cohort
Authors
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Autopsy insights into DES restenosis mechanisms warrant caution in living patients; leaves open whether neointimal differences vs BMS guide future therapies.
Observational (n=82)
What are the histomorphological predictors and neointimal characteristics of drug-eluting stent restenosis compared to bare metal stents?
Odds Ratio: 17.4
p-value: p=0.04
Wider inter-strut distance and vessel injury are primary mechanisms of DES restenosis and occlusion, with DES showing greater proteoglycan deposition than BMS.
Nakano et al. (2013) conducted an observational in Drug-eluting stent restenosis (n=82). Drug-eluting stents vs. Bare metal stents was evaluated on DES restenosis (OR 17.4, p=0.04). Wider inter-strut distance was strongly associated with drug-eluting stent restenosis (OR 17.4, P=0.04), and medial tear length predicted stent occlusion (OR 5.1, P=0.03) in an autopsy registry.
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