Key result
Male sex was significantly associated with a reduced risk of major adverse cardiovascular events (OR 0.113) following multi-vessel percutaneous coronary intervention compared to female sex.
Why the study?
What are the clinical and anatomical predictors of procedural success and major cardiovascular events in Filipino patients undergoing multi-vessel percutaneous coronary intervention?
Cohort (n=1,030)
No
What are the clinical and anatomical predictors of procedural success and major cardiovascular events in Filipino patients undergoing multi-vessel percutaneous coronary intervention?
Odds Ratio: 0.113 (95% CI 0.025–0.517)
p-value: p=0.005
Patient demographics, clinical presentation, and anatomical complexity significantly predict procedural success and clinical outcomes in Filipino patients undergoing multi-vessel PCI.
May support risk stratification for MV-CAD PCI; hypothesis-generating and requires prospective validation.
Background: The leading cause of mortality in the country is heart disease with a rate of 94.5 deaths per 100,000 Filipinos. Multi-vessel coronary artery disease (MV-CAD) patients carry an increased procedural risk especially those with increased lesion complexity or unfavorable anatomy. Objective: The study aims to determine the variables that will predict procedural success and clinical outcome among MV-CAD patients undergoing percutaneous coronary intervention Setting: Philippine Heart Center , Quezon Ci ty, Philippines Methodology: This retrospective cohort study obtained data from the four-year Philippine Heart Center Registry consisting of 1,030 patients who underwent Multi-Vessel Percutaneous Coronary Intervention (MV-PCI) from January 2009 to January 2012 at the Cardiac Catheterization Laboratory. Results: Significant predictors for improved procedural success and reduced risk for major cardiovascular events was evident in male patients, those with mild diastolic dysfunction (grade I or II) and patients on statin therapy. The variables with unfavorable procedural and clinical outcome are female patients, those with unstable angina, STEMI, heart failure, COPD, the need for IABP counterpulsation and a left main artery coronary lesion. Conclusion: The results reflect a local “real-life scenario” providing important information on the predictors of outcome among Filipino patients with multi-vessel disease undergoing percutaneous coronary intervention. The information obtained is clinically relevant for both cardiologist and interventionist providing an important risk strat i f icat ion and contributing to the holistic delivery of cardiovascular care.
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Ines et al. (2015) conducted a cohort in Multi-Vessel Coronary Artery Disease (n=1,030). Male sex vs. Female sex was evaluated on Major Adverse Cardiovascular Events (MACE) (OR 0.113, 95% CI 0.025-0.517, p=0.005). Male sex was significantly associated with a reduced risk of major adverse cardiovascular events (OR 0.113) following multi-vessel percutaneous coronary intervention compared to female sex.
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