Key result
A comprehensive understanding of the mechanisms of cardiotoxicity from non-cardiovascular drugs is essential for appropriate drug selection, cardioprotection, and new drug development.
Understanding the mechanisms of cardiotoxicity from non-cardiovascular drugs is essential for appropriate drug selection and development of targeted therapies.
Understanding cardiotoxicity mechanisms guides safer drug selection and cardioprotective strategies; reinforces Level 1 guidelines for clinicians and researchers.
Cardiotoxicity has evolved as an essential component of various adverse drug reactions and an important aspect in drug development and withdrawal. A triphasic interaction of the drug, its mechanism of action on the heart and various factors influencing toxicity is the basis of various cardiotoxicities. A comprehensive knowledge of the various mechanisms of cardiotoxicities and classes of drug causing it would promote appropriate drug selection, simultaneous use of cardioprotective drugs and work as a guideline for the development of new drugs and targeted therapies. A check in the drug causes of cardiotoxicities would definitely play a vital role in eliminating a significant fraction of the cardiovascular diseases and delay the rate and magnitude of the development of the impending cardiovascular disease epidemic. Birdem Med J 2013; 3(1): 35-43 DOI: http://dx.doi.org/10.3329/birdem.v3i1.17125
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Rashid et al. (2013) conducted a review in Cardiotoxicity. Non-cardiovascular drugs was evaluated. A comprehensive understanding of the mechanisms of cardiotoxicity from non-cardiovascular drugs is essential for appropriate drug selection, cardioprotection, and new drug development.
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