What question did this study set out to answer?

This research aims to evaluate the susceptibility of Mycobacterium tuberculosis to trimethoprim-sulfamethoxazole (TMP-SMX) and its potential use as a treatment option.

June 30, 2009Antimicrobial Agents and ChemotherapyOpen Access

Tuberculosis and Trimethoprim-Sulfamethoxazole

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This research aims to evaluate the susceptibility of Mycobacterium tuberculosis to trimethoprim-sulfamethoxazole (TMP-SMX) and its potential use as a treatment option.
Conducted susceptibility testing of M. tuberculosis isolates on supplemented Middlebrook 7H10 plates.
Analyzed 44 different isolates for response to TMP-SMX treatment.
Identified the minimum inhibitory concentration (MIC) for TMP and SMX.
98% of M. tuberculosis isolates (43 of 44) were found to be susceptible to TMP-SMX at an MIC of ≤1 microg/ml for TMP and 19 microg/ml for SMX.
Susceptibility levels were similar to those observed in Mycobacterium kansasii and Mycobacterium marinum.
Highlighted the potential for TMP-SMX to be effective in treating multiple-drug-resistant and extended drug-resistant tuberculosis.

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Implication

Randomized trial assesses TMP-SMX effectiveness in treating tuberculosis, suggesting renewed interest in sulfonamides.

Cite This Study

Forgacs et al. (2009) studied this question.

synapsesocial.com/papers/6a6537a5bb6f8f4ddd7dc202 https://doi.org/10.1128/aac.01658-08

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Tuberculosis and Trimethoprim-Sulfamethoxazole

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Discussion

Implication

Cite This Study

Tuberculosis and Trimethoprim-Sulfamethoxazole

Key Points

Discussion

Implication

Cite This Study

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