Key result
SV40 T antigen is required for viral excision from host chromosomes, as only T-antigen positive cell lines yielded infectious virus after cell fusion with CV-1 cells.
Population
Rat 2 cells, COS-7 cells, and CV-1 cells
Design
Preclinical
Authors
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T antigen dependence suggests targeted antiviral research; leaves open validation in human polyomavirus models.
SV40 T antigen is required for viral excision from host chromosomes prior to or during homologous recombination.
Miller et al. (1984) studied SV40 viral excision. SV40 T antigen vs. T-antigen negative plasmids was evaluated on Yield of infectious virus after cell fusion. SV40 T antigen is required for viral excision from host chromosomes, as only T-antigen positive cell lines yielded infectious virus after cell fusion with CV-1 cells.
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