Construction of Quaternary Stereocenters by Efficient and Practical Conjugate Additions to α,β‐Unsaturated Ketones with a Chiral Organic Catalyst

Added value: The conjugate addition of cyclic or acyclic α-substituted β-ketoesters to α,β-unsaturated ketones using a chiral organic catalyst (1) can be achieved with good enantioselectivity, diastereoselectivity, and yield. This asymmetric CC bond formation strategy provides a range of chiral building blocks 2 that contain an all-carbon quaternary stereocenter.