Novel insights into the regulation of neuron migration by axon guidance proteins

Neural circuit development requires precisely coordinated guidance of migrating neurons to their targets within the nervous system. A diverse array of molecular cues has been implicated in neuron migration, including signals originally identified for their ability to dictate the trajectories of growing axons, i.e. axon guidance proteins. These proteins are now known to have pleiotropic effects affecting different stages of neuron migration, from promoting cell mobility to acting as stop signals. In this review, we discuss recent advances in our understanding of how canonical axon guidance proteins influence migrating neurons with a particular focus on recent insights into how neuron migration is controlled in the GnRH system and cortex, and the multifunctional role of Netrin-1. At the molecular level, tight control of receptor expression and crosstalk, and interactions with the extracellular matrix have recently been implicated in neuron migration control.