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January 10, 2025BMC Cardiovascular DisordersOpen Access

Bioinformatics analysis of ferroptosis-related hub genes and immunoinfiltration in myocardial ischemia/reperfusion following heart transplantation

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Authors

YZYuxi ZhangQTQiao TangJCJiahui Cui

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Overview

Randomized trial explores the impact of ferroptosis on myocardial ischemia/reperfusion in heart transplantation, suggesting potential therapeutic targets.

Key Points

  • This study aims to explore the effect of ferroptosis on ischemia/reperfusion during heart transplantation.
  • Differentially expressed genes were identified via GEO2R from GSE50884 data.
  • Ferroptosis-related DEGs were screened using Venn diagrams with genes from the FerDb database.
  • Immunoinfiltration analysis was conducted using CIBERSORTx to assess immune cell infiltration in myocardial ischemia/reperfusion.
  • 12 ferroptosis-related DEGs were identified from 327 DEGs in GSE50884.
  • Three hub genes (SLC7A11, PSAT1, ASNS) were identified and correlated with several immune cells.
  • Expression of hub genes was significantly higher in I/R models compared to normal tissues as verified by RT-qPCR and western blot.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/6a6547a3e79d3b1ece032d64https://doi.org/10.1186/s12872-024-04462-1
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