Key result
The S4 segment of the KvAP channel is located at the protein/lipid interface and is highly dynamic, while the S1 segment is surrounded by other parts of the protein at the contact interface.
Population
Prokaryotic voltage-dependent K+ channel (KvAP) in a lipid bilayer
Design
Preclinical
Authors
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Structural dynamics of KvAP S4 may refine cardiac channel models; leaves open translation to human Kv function.
This study establishes the general principles of voltage-dependent channel structure in a biological membrane by elucidating the positions and dynamics of the S1 and S4 segments of the KvAP channel.
Cuello et al. (2004) studied this question. The S4 segment of the KvAP channel is located at the protein/lipid interface and is highly dynamic, while the S1 segment is surrounded by other parts of the protein at the contact interface.
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