Population
Mammalian HCN pacemaker channels (HCN1 engineered to be MTS resistant except for chosen S4 Cys substitution)
Comparison
External or internal MTSET application vs Closed vs open state of the channel
Design
Preclinical
Authors
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Challenges classical HCN gating models in animals; leaves open relevance to human cardiac pacemaking.
Voltage sensing in HCN channels may be driven by rearrangements in surrounding transmembrane segments that alter the membrane field around a relatively static S4 segment, challenging classical gating models.
Bell et al. (2003) studied this question.
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