August 26, 2002The Journal of General PhysiologyOpen Access

Movement and Crevices Around a Sodium Channel S3 Segment

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Population

Sodium channel Na(v)1.4

Design

Preclinical

Authors

TNThao P. NguyenWhitehead Institute for Biomedical Research RHRichard HornSequans Communications (United Kingdom)

Discussion

Member takes

Implication

Refines NaV1.4 gating models in animal systems; hypothesis-generating with no immediate clinical implications.

Structured PICO

Population

Sodium channel Na(v)1.4

Intervention

Cysteine substitutions at nine putative 'high impact' sites along D4/S3 and probing with extracellular sulfhydryl reagents and photoactivatable cross-linking reagent

Outcome

Accessibility to extracellular sulfhydryl reagents and voltage-dependent modification ratessurrogate

This basic science study provides mechanistic insights into the voltage-dependent gating of the Na(v)1.4 sodium channel, demonstrating that the extracellular crevice near the D4/S3 segment widens during depolarization.

Cite This Study

Nguyen et al. (2002) studied this question.

synapsesocial.com/papers/6a700a95439bab0cabc2fe88 https://doi.org/10.1085/jgp.20028636

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Movement and Crevices Around a Sodium Channel S3 Segment

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Movement and Crevices Around a Sodium Channel S3 Segment

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider