Key result
Higher handgrip strength (highest tertile) was associated with a significantly lower risk of incident aortic stenosis compared to the lowest tertile (HR 0.76).
Why the study?
The association between handgrip strength and the incidence of aortic stenosis among adults aged 60 years and older had not been examined.
Does higher handgrip strength predict a lower incidence of aortic stenosis in adults aged 60 years and older?
Cohort (n=157,097)
Yes
Does higher handgrip strength predict a lower incidence of aortic stenosis in adults aged 60 years and older?
Hazard Ratio: 0.76 (95% CI 0.67–0.87)
Absolute Event Rate: 0.8% vs 1.3%
p-value: p=<0.001
Higher handgrip strength is independently associated with a lower risk of developing incident aortic stenosis in older adults, suggesting its potential utility as a simple risk stratification tool.
Supports grip strength assessment in aortic stenosis risk models; hypothesis-generating and should not yet change practice.
Objective: To examine the association of handgrip strength with aortic stenosis incidence among adults aged 60 years and older. Methods: We conducted a cohort study using the UK Biobank data to assess the relationship between handgrip strength and incident aortic stenosis in individuals aged 60 years and older. Handgrip strength was measured using a Jamar J00105 hydraulic hand dynamometer. Adjusted Cox proportional hazards regression models were conducted to assess the association between handgrip strength and incident aortic stenosis. Results: We included 157,097 UK Biobank participants (78,151 women and 78,946 men) in our study, with mean age of 64 ± 2.9 years. During a median follow-up of 8.1 (7.4-8.8) years, 1543 (1.0%) participants developed incident aortic stenosis. Compared with those with the lowest handgrip strength (tertile 1), the adjusted hazard ratios (95% confidence interval) of incident aortic stenosis in the middle (tertile 2) and the highest (tertile 3) were 0.86 (0.77-0.97) and 0.76 (0.67-0.87), respectively. Conclusions: Higher handgrip strength was associated with lower risk of developing aortic stenosis in older adults. Future studies warrant preventive strategies for older adults with lower handgrip strength.
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Song et al. (2024) conducted a cohort in Aortic stenosis (n=157,097). Higher handgrip strength (highest tertile) vs. Lowest tertile of handgrip strength was evaluated on Incident aortic stenosis (HR 0.76, 95% CI 0.67-0.87, p=<0.001). Higher handgrip strength (highest tertile) was associated with a significantly lower risk of incident aortic stenosis compared to the lowest tertile (HR 0.76).
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