Key result
Intravenous magnesium sulphate (30 mg/kg) administered before extubation significantly reduced heart rate (94.26 vs 104.03 bpm, p=0.015) and systolic blood pressure compared to placebo in patients undergoing craniotomies.
RCT (n=60)
Double-blind
Computer generated random number table
No
Magnesium may blunt extubation surges in craniotomy patients; leaves open whether routine use improves outcomes.
During emergence of general anaesthesia, hypertension and tachycardia caused by tracheal extubation may lead to serious complications during craniotomies. This study was designed to assess the effect of magnesium sulphate on these cardiovascular responses during extubation following craniotomies under general anaesthesia.
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Goyal et al. (2017) conducted an RCT in Nonvascular intracranial space-occupying lesions (ICSOL) requiring craniotomy (n=60). Magnesium sulphate vs. Normal saline was evaluated on Heart rate at the time of extubation (beats per minute) (p=0.015). Intravenous magnesium sulphate (30 mg/kg) administered before extubation significantly reduced heart rate (94.26 vs 104.03 bpm, p=0.015) and systolic blood pressure compared to placebo in patients undergoing craniotomies.
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