Key result
Magnesium sulfate administered before endotracheal intubation significantly attenuated the increase in mean arterial pressure (P<0.05) and systemic vascular resistance (P<0.01) compared to lidocaine.
Why the study?
Does magnesium sulfate attenuate adverse hemodynamic responses to endotracheal intubation in patients with coronary artery disease?
Population
36 patients with coronary artery disease (CAD) scheduled for elective coronary artery bypass grafting
Comparison
Magnesium sulfate 50 mg/kg before induction of… vs Isotonic sodium chloride solution before…
Design
Other
Follow-up
Perioperative period (throughout endotracheal intubation)
Authors
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Should not alter intubation practices in CAD; leaves open superiority over lidocaine pending randomized trials.
RCT (n=36)
Does magnesium sulfate attenuate adverse hemodynamic responses to endotracheal intubation in patients with coronary artery disease?
p-value: p=<0.05
Magnesium sulfate administered before endotracheal intubation effectively attenuates adverse hemodynamic responses in patients with coronary artery disease better than lidocaine.
Puri et al. (1998) conducted an RCT in Coronary artery disease (n=36). Magnesium sulfate vs. Isotonic sodium chloride before induction and lidocaine 1 mg/kg before intubation was evaluated on Hemodynamic response to endotracheal intubation (increase in mean arterial pressure and systemic vascular resistance) (p=<0.05). Magnesium sulfate administered before endotracheal intubation significantly attenuated the increase in mean arterial pressure (P<0.05) and systemic vascular resistance (P<0.01) compared to lidocaine.
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