Key result
In patients with COPD, the presence of cor pulmonale was associated with higher mean CAT scores (16.59 vs 14.06) compared to those without, though the difference was not significant (p>0.05).
Why the study?
The study was conducted to compare arterial blood gas patterns in COPD patients with versus without cor pulmonale.
Observational (n=100)
No
Absolute Event Rate: 16.59% vs 14.06%
p-value: p=>0.05
There was no significant difference in CAT or mMRC scores between COPD patients with and without cor pulmonale, though ABG analysis is recommended for monitoring.
May support differential ABG monitoring by cor pulmonale status in COPD; hypothesis-generating and requires prospective validation.
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is a major public health problem. COR PULMONALE describes the enlargement and failure of the right ventricle of the heart as a response to increased vascular resistance or increased pulmonary artery pressure. Hypoxic pulmonary vasoconstriction, hypercapnia, respiratory acidosis and pulmonary vascular remodeling in COPD can cause an increase in right ventricular (RV) after load, which in turn, results in RVfailure leading to COR PULMONALE AIM:The purpose of the study is to compare the ABG pattern in patients of COPD with or without COR PULMONALE. MATERIALS AND METHODS: This prospective observational study was conducted in the Department of Medicine of DMCH, Laheriasarai, Bihar. The study was conducted with duration of 2 years. Atotal of 100 patients admitted as a case of COPD with or without COR PULMONALE. The patients were put into two subgroups, COPD with and without COR PULMONALE. RESULT: The mean duration was 10.17 years and 9.20 years respectively in patients with and without COR PULMONALE. There was no statistically signicant difference regarding mean duration of disease (p value =0.304). Mean CAT score was 16.59 ± 6.26 and mean mMRC was 3.19± 0.45 in COPD patients with COR PULMONALE group. Mean CAT score was 14.06 ± 4.46 and mean mMRC was 3.10 ± 0.44 in COPD patients without COR PULMONALE group. We found no signicant difference among these variables between groups. Although COR PULMONALE patients had higher CATscore and mMRC score, the difference was not signicant (p value = >0.05). CONCLUSION:ABG ANALYSIS should be recommended for all patients of COPD with or without COR PULMONALE to assess the degree of hypoxemia, hypercapnea, respiratory acidosis and also, we can identify individuals who need more close monitoring and intensive treatment.
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Alam et al. (2021) conducted an observational in Chronic obstructive pulmonary disease (COPD) with or without cor pulmonale (n=100). Cor pulmonale vs. No cor pulmonale was evaluated on CAT score (p=>0.05). In patients with COPD, the presence of cor pulmonale was associated with higher mean CAT scores (16.59 vs 14.06) compared to those without, though the difference was not significant (p>0.05).
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