Key result
Gallic acid significantly preserved cardiac function, including heart rate and QRS voltage, and attenuated oxidative stress and inflammation in rats with elastase-induced lung injury.
Why the study?
Cardiovascular disease contributes significantly to mortality in lung injury, prompting evaluation of whether antioxidant and anti-inflammatory gallic acid protects against lung and related heart dysfunction in elastase-induced lung injury.
Does gallic acid improve cardiac function and reduce oxidative stress and inflammation in an elastase-induced lung injury model?
Does gallic acid improve cardiac function and reduce oxidative stress and inflammation in an elastase-induced lung injury model?
In a rat model of elastase-induced lung injury, gallic acid demonstrated potential therapeutic effects in preventing oxidative stress, inflammation, and subsequent cardiac dysfunction.
No immediate clinical implications; hypothesis-generating for gallic acid in lung injury models.
OBJECTIVES: Cardiovascular disease has an important role in mortality caused by lung injury. Emphysema is associated with impaired pulmonary gas exchange efficiency and airflow limitation associated with small airway inflammation. The aim was to evaluate the interactions between lung injury, inflammation, and cardiovascular disease. Since gallic acid has antioxidant and anti-inflammatory effects, we hypothesized that gallic acid protects the lung and the related heart dysfunction in elastase-induced lung injury. MATERIALS AND METHODS: Forty-eight Sprague-Dawley male rats were randomly divided into six groups: Control, Porcine pancreatic elastase (PPE) , PPE+GA, and 3 groups for different doses of gallic acid (GA 7.5, GA 15, GA 30 mg/kg). PPE was injected intra-tracheally on days 1 and 10 of the test. In each group, electrocardiography, hemodynamic parameters, oxidative stress, and bronchoalveolar lavage fluid were examined. RESULTS: <0.001) showed an increase in PPE groups. Gallic acid preserved the values of hemodynamic properties, oxidative stress, inflammation, and electrocardiogram parameters in comparison to the PPE group. CONCLUSION: Briefly, this study showed the valuable effect of gallic acid in cardiac dysfunction related to elastase-induced lung injury. These findings suggested that gallic acid, as a natural antioxidant, has a potential therapeutic effect on preventing oxidative stress, inflammation, and subsequent cardiovascular disease.
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Sohrabi et al. (2020) studied Elastase-induced lung injury (emphysema) and related cardiac dysfunction (n=48). Gallic acid vs. Porcine pancreatic elastase (PPE) alone was evaluated on Heart rate (bpm) (p=<0.01). Gallic acid significantly preserved cardiac function, including heart rate and QRS voltage, and attenuated oxidative stress and inflammation in rats with elastase-induced lung injury.
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