July 1, 2009Autophagy271 citationsOpen Access
View Full PaperRapamycin inhibits mTORC1, but not completely
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Abstract
Rapamycin is widely used as a complete inhibitor of the mTORC1 nutrient-sensitive signaling complex. Using a novel ATP-competitive inhibitor named Torin1, we have found that many mTORC1 functions that regulate cap-dependent translation and autophagy are resistant to inhibition by rapamycin.