A Constituent of Green Tea, Epigallocatechin-3-gallate, Activates Endothelial Nitric Oxide Synthase by a Phosphatidylinositol-3-OH-kinase-, cAMP-dependent Protein Kinase-, and Akt-dependent Pathway and Leads to Endothelial-dependent Vasorelaxation

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Intervention: Epigallocatechin-3-gallate (EGCG) vs. Vehicle/control. Primary outcome: Vasorelaxation and eNOS expression and activity.

Mario Lorenz; Silja Weßler; Elena Follmann; Wanda Michaelis; Thomas Düsterhöft; Gert Baumann; Karl Stangl; Verena Stangl

doi:10.1074/jbc.m309114200

February 1, 2004Journal of Biological ChemistryOpen Access

A Constituent of Green Tea, Epigallocatechin-3-gallate, Activates Endothelial Nitric Oxide Synthase by a Phosphatidylinositol-3-OH-kinase-, cAMP-dependent Protein Kinase-, and Akt-dependent Pathway and Leads to Endothelial-dependent Vasorelaxation

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Key result

EGCG stimulates dose-dependent vasodilation through rapid Akt- and PKA-dependent activation of eNOS.

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Intervention / Comparator

Epigallocatechin-3-gallate (EGCG) vs Vehicle/control (1-50 μm)

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Primary Outcome

Vasorelaxation and eNOS expression and activity

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Lorenz et al. (2004) studied this question. Epigallocatechin-3-gallate (EGCG) vs. Vehicle/control was evaluated on Vasorelaxation and eNOS expression and activity. Epigallocatechin-3-gallate (EGCG) induced dose-dependent endothelium-dependent vasodilation by rapid PI3K-, PKA-, and Akt-dependent activation of eNOS, without altering eNOS protein levels.

synapsesocial.com/papers/6a655828792083995339eda3 https://doi.org/10.1074/jbc.m309114200

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A Constituent of Green Tea, Epigallocatechin-3-gallate, Activates Endothelial Nitric Oxide Synthase by a Phosphatidylinositol-3-OH-kinase-, cAMP-dependent Protein Kinase-, and Akt-dependent Pathway and Leads to Endothelial-dependent Vasorelaxation

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A Constituent of Green Tea, Epigallocatechin-3-gallate, Activates Endothelial Nitric Oxide Synthase by a Phosphatidylinositol-3-OH-kinase-, cAMP-dependent Protein Kinase-, and Akt-dependent Pathway and Leads to Endothelial-dependent Vasorelaxation

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