Key result
Subcutaneous G-CSF reduces cerebral infarct volume and improves motor performance in ischemic stroke.
BACKGROUND: Stroke is a leading cause of death and disability worldwide; however, no effective treatment currently exists. METHODS AND RESULTS: Rats receiving subcutaneous granulocyte colony-stimulating factor (G-CSF) showed less cerebral infarction, as evaluated by MRI, and improved motor performance after right middle cerebral artery ligation than vehicle-treated control rats. Subcutaneous administration of G-CSF enhanced the availability of circulating hematopoietic stem cells to the brain and their capacity for neurogenesis and angiogenesis in rats with cerebral ischemia. CONCLUSIONS: G-CSF induced increases in bone marrow cell mobilization and targeting to the brain, reducing the volume of cerebral infarction and improving neural plasticity and vascularization.
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Shyu et al. (2004) studied Cerebral ischemia / Stroke. Granulocyte colony-stimulating factor (G-CSF) vs. Vehicle-treated control was evaluated on Cerebral infarction and motor performance.
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