Key result
Glucocorticoid exposure is linked to ~0.8 m/s lower cfPWV, suggesting reduced central arterial stiffness.
Why the study?
This study aimed to assess variables concerning arterial stiffness and the advancement of atherosclerosis development, including carotid-femoral and carotid-radial pulse wave velocity and ankle-brachial index, in patients with systemic lupus erythematosus.
Does long-term glucocorticoid treatment alter arterial stiffness and atherosclerosis progression in adult patients with systemic lupus erythematosus?
Cross-Sectional (n=43)
No
Does long-term glucocorticoid treatment alter arterial stiffness and atherosclerosis progression in adult patients with systemic lupus erythematosus?
Answers are grounded in this paper and cite their sources.
Low-dose glucocorticoids may have differential effects on the vascular system in SLE, potentially decreasing central arterial stiffness while being associated with increased carotid intima-media thickness.
Objectives: This study aims to assess variables concerning arterial stiffness including carotid-femoral pulse wave velocity, carotid-radial pulse wave velocity, ankle-brachial index, and the advancement of atherosclerosis development. Patients and methods: Between October 2016 and December 2020, a total of 43 consecutive patients with systemic lupus erythematosus (SLE) (4 males, 39 females; mean age: 57±8 years; range, 42 to 65 years) were prospectively included in the study. All data were compared between the group treated with glucocorticoids and that not treated with these agents. Results: The study group consisted of 43 patients with SLE, while 22 (51%) patients were treated with glucocorticoids. The mean duration of SLE was 12.3±5.3 years. Patients treated with glucocorticoids had lower values of ankle-brachial index compared to those who were not treated with glucocorticoids (p=0.041), although the values were within the range. A similar situation was reported for the carotid-femoral artery pulse wave velocity (p=0.032). However, carotid-radial artery pulse wave velocity was not significantly different between both groups (p=0.12). Conclusion: Properly selected therapy is important in the prevention of CVD.
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Blachut et al. (2022) conducted a cross-sectional in Systemic lupus erythematosus (n=43). Glucocorticoids vs. No glucocorticoid therapy was evaluated on Carotid-femoral pulse wave velocity (cfPWV) (p=0.032). Glucocorticoid exposure was associated with lower carotid-femoral pulse wave velocity compared to no glucocorticoid treatment, suggesting reduced central arterial stiffness.
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