Key result
Peripheral nerve injury and CRPS type II were associated with greater α1-adrenoceptor expression on cutaneous nerve fibres compared to unaffected skin or pain-free controls.
Population
Animal model of neuropathic pain and patients with complex regional pain syndrome type II after peripheral…
Comparison
Partial sciatic nerve ligation and peripheral… vs Sham surgery and unaffected skin from the same…
Design
Preclinical
Follow-up
4 days (animal model)
Authors
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Suggests a peripheral mechanism for sympathetically maintained pain in complex regional pain syndrome; leaves open whether.
Observational
Peripheral nerve injury induces upregulation of α1-adrenoceptors on cutaneous nociceptive afferents, potentially contributing to chronic pain in CRPS type II.
Drummond et al. (2013) conducted an observational in Complex regional pain syndrome type II. Peripheral nerve injury and CRPS vs. Unaffected skin and pain-free controls (human); sham surgery (animal) was evaluated on α1-adrenoceptor expression on cutaneous nerve fibres. Peripheral nerve injury and CRPS type II were associated with greater α1-adrenoceptor expression on cutaneous nerve fibres compared to unaffected skin or pain-free controls.
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