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Abstract CD4 + T cells play a notable role in immune protection at different stages of life. During aging, the interaction between the body's internal and external environment and CD4 + T cells results in a series of changes in the CD4 + T cells pool making it involved in immunosenescence. Many studies have extensively examined the subsets and functionality of CD4 + T cells within the immune system, highlighted their pivotal role in disease pathogenesis, progression, and therapeutic interventions. However, the underlying mechanism of CD4 + T cells senescence and its intricate association with diseases remains to be elucidated and comprehensively understood. By summarizing the immunosenescent progress and network of CD4 + T cell subsets, we reveal the crucial role of CD4 + T cells in the occurrence and development of age‐related diseases. Furthermore, we provide new insights and theoretical foundations for diseases targeting CD4 + T cell subsets aging as a treatment focus, offering novel approaches for therapy, especially in infections, cancers, autoimmune diseases, and other diseases in the elderly.
Xia et al. (Sun,) studied this question.