This case reports the first successful use of combination dupilumab and low-dose acitretin therapy in a patient with genetically confirmed Galli-Galli Disease, achieving rapid resolution of pruritus and marked clinical improvement within 6 weeks after years of inadequate response to conventional treatments.This regimen offers a promising, well-tolerated therapeutic option for clinicians managing this rare acantholytic genodermatosis with otherwise limited treatment options.
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Reedy et al. (2026) studied this question.
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