Untreated asymptomatic bacteriuria in girls: II--Effect of phenoxymethylpenicillin and erythromycin given for intercurrent infections.

April 1, 1989BMJOpen Access

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Key Points

To investigate the effects of phenoxymethylpenicillin and erythromycin on urinary isolates from girls with untreated asymptomatic bacteriuria.
Retrospective study of 51 girls aged under 15 with untreated asymptomatic bacteriuria from a cohort followed up till 1986.
Patients treated with phenoxymethylpenicillin before 1982 and erythromycin after 1982 for intercurrent infections.
Bacterial strains identified by serotype and electrophoretic type were compared before and after antibiotic treatment.
Treatment with phenoxymethylpenicillin resulted in bacterial strain change and symptomatic recurrences in about 15% of patients.
Erythromycin treatment showed rare changes in bacteriuria with no symptomatic recurrences.
Overall, phenoxymethylpenicillin increased the risk of acute pyelonephritis, while erythromycin posed a lower risk (2 out of 20 courses).

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Retrospective study examines antibiotic impact on urinary bacteria in girls, highlighting risks of symptom recurrence.

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Hansson et al. (1989) studied this question.

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