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October 7, 2005Journal of Cellular Biochemistry

deltaCaMKII expression was enhanced in regenerating skeletal muscle fibers of normal mice and mdx mice, despite an overall decrease in deltaCaMKII content in dystrophic muscle.

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Key result

deltaCaMKII expression was enhanced in regenerating skeletal muscle fibers of normal mice and mdx mice, despite an overall decrease in deltaCaMKII content in dystrophic muscle.

Authors

SAS. Thomas AbrahamCSCarisa Shaw

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Overview

Hypothesis-generating for CaMKII in dystrophic regeneration; leaves open clinical translation pending human validation.

PICO

P
Population
Normal mice and 4 to 6 week old mdx mice used as models to study skeletal muscle regeneration.
E
Exposure / Comparator
Muscle necrosis and regeneration (glycerol-induced or mdx mutation) vs Age-matched control mice (50% glycerol)
O
Primary Outcome
deltaCaMKII expression

Cite This Study

Abraham et al. (2005) studied Skeletal muscle regeneration and dystrophic muscle disease. Muscle necrosis and regeneration (glycerol-induced or mdx mutation) vs. Age-matched control mice was evaluated on deltaCaMKII expression. deltaCaMKII expression was enhanced in regenerating skeletal muscle fibers of normal mice and mdx mice, despite an overall decrease in deltaCaMKII content in dystrophic muscle.

synapsesocial.com/papers/6a656afd2d34c0d4ae2d69bbhttps://doi.org/10.1002/jcb.20669
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Also Consider

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  4. 4Identification of novel isoforms of the delta subunit of Ca2+/calmodulin-dependent protein kinase II. Differential expression in rat brain and aorta1993 · 150 citations
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