Key result
Pregnancy in women with Marfan syndrome was associated with increased odds of obstetric complications (OR 3.29; 95% CI 1.30-8.34) and small for gestational age neonates (24% vs 6%).
Why the study?
Does Marfan syndrome increase the risk of maternal and neonatal mortality and morbidity during pregnancy compared to healthy controls?
Population
29 pregnancies in 21 women with Marfan syndrome (MFS) between 1995 and 2010, and healthy controls.
Comparison
Pregnancy in women with Marfan syndrome vs Pregnancy in healthy controls
Design
Cohort
Follow-up
Up to 6 months post-delivery
Authors
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Supports multidisciplinary MFS pregnancy care in tertiary centers; leaves open need for larger prospective studies.
Observational (n=21)
Yes
Does Marfan syndrome increase the risk of maternal and neonatal mortality and morbidity during pregnancy compared to healthy controls?
Odds Ratio: 3.29 (95% CI 1.3–8.34)
Pregnancy in women with Marfan syndrome is associated with significant maternal cardiac and obstetric complications, as well as an increased risk of the neonate being small for gestational age, necessitating multidisciplinary care.
Curry et al. (2014) conducted an observational in Marfan syndrome in pregnancy (n=21). Marfan syndrome vs. Healthy controls was evaluated on Obstetric complications (OR 3.29, 95% CI 1.30-8.34). Pregnancy in women with Marfan syndrome was associated with increased odds of obstetric complications (OR 3.29; 95% CI 1.30-8.34) and small for gestational age neonates (24% vs 6%).
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