Key result
Fetuses with meconium-stained amniotic fluid had significantly lower umbilical cord NTpBNP levels at birth compared to controls with clear amniotic fluid (1.01 vs 1.70 ng/ml, p=0.01).
Why the study?
Are NTpBNP levels altered in fetuses with meconium-stained amniotic fluid compared to normal controls?
Case-Control (n=36)
No
Are NTpBNP levels altered in fetuses with meconium-stained amniotic fluid compared to normal controls?
Answers are grounded in this paper and cite their sources.
Fetal umbilical cord NT-proBNP levels are significantly decreased in fetuses with meconium-stained amniotic fluid, suggesting its potential as a biomarker in this setting.
PURPOSE OF INVESTIGATION: To evaluate the value of N terminal-pro brain natriuretic peptide (NTpBNP) levels in fetuses with meconiumtained amniotic fluid (MSAF). MATERIALS AND METHODS: In this case control study, of 36 fetuses, 19 had MSAF and 17 had normal, as controls. The blood samples were taken from the fetal umbilical cord just after birth to measure NTpBNP levels. RESULTS: Mean NTpBNP values were 1.01 ± 0.49 ng/ml in the patient group and 1.70 ± 0.93 ng/ml in the control group. The difference between the groups was statistically significant (p = 0.01) and power was 78% at 95% confidence interval. CONCLUSION: Serum NTpBNP levels were decreased in the study group. The result suggests that NTpBNP may be a valuable marker for fetuses with MSAF.
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Kaba et al. (2016) conducted a case-control in Meconium-stained amniotic fluid (n=36). Meconium-stained amniotic fluid vs. Clear amniotic fluid was evaluated on N terminal-pro brain natriuretic peptide (NTpBNP) levels in fetal umbilical cord blood (p=0.01). Fetuses with meconium-stained amniotic fluid had significantly lower umbilical cord NTpBNP levels at birth compared to controls with clear amniotic fluid (1.01 vs 1.70 ng/ml, p=0.01).
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