Key result
Plasma clearance of 99mTc-DTPA was highly correlated with 51Cr-EDTA (r=0.993) with a minimal mean difference of 1.4 mL/min (95% LOA -6.6 to 9.4; P=0.01), indicating it is a suitable replacement.
Why the study?
Both 99mTc-DTPA and 51Cr-EDTA are widely used to measure GFR, but few direct comparisons exist, making assessment relevant given 51Cr-EDTA shortages.
Does 99mTc-DTPA provide comparable plasma clearance measurements to 51Cr-EDTA in adult patients referred for routine GFR measurement?
Comparison
99mTc-DTPA vs 51Cr-EDTA simultaneous plasma clearance
Design
Prospective comparative study
Follow-up
240 min
Authors
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Prospective comparison of 99mTc-DTPA versus 51Cr-EDTA for GFR is hypothesis-generating; larger studies needed before substitution.
Cross-Sectional (n=56)
Does 99mTc-DTPA provide comparable plasma clearance measurements to 51Cr-EDTA in adult patients referred for routine GFR measurement?
Mean Difference: 1.4 (95% CI -6.6–9.4)
p-value: p=0.01
99mTc-DTPA can safely replace 51Cr-EDTA for routine GFR measurement, as there are no clinically relevant differences in plasma clearance between the two tracers.
Andersen et al. (2019) conducted a cross-sectional in referred for routine GFR measurement (n=56). 99mTc-DTPA vs. 51Cr-EDTA (2.5 MBq) was evaluated on plasma clearance (MD 1.4 mL/min, 95% CI -6.6 to 9.4, p=0.01). Plasma clearance of 99mTc-DTPA was highly correlated with 51Cr-EDTA (r=0.993) with a minimal mean difference of 1.4 mL/min (95% LOA -6.6 to 9.4; P=0.01), indicating it is a suitable replacement.
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