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Research demonstrates the evolution of biosynthetic gene cluster regulation through transcription factor repurposing, suggesting implications for gene function.
has functionally diverged to regulate different BGCs in these two species emphasizes that the diversification of BGC regulatory elements may sometimes occur through exaptation, which is the co-option of a gene that evolved for one function to a novel function. Furthermore, this work suggests that the loss/gain of transcription factor binding site targets may be an important mediator in the evolution of secondary-metabolism regulatory elements.
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Wang et al. (2021) studied this question.
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