Key result
Aortic pulse wave velocity in patients with chronic kidney disease significantly increased by 1.1 m/s over 1 year (P<.01), with accelerated progression associated with age, systolic blood pressure, and diabetes.
Why the study?
What is the natural progression of aortic pulse wave velocity over 12 months in patients with chronic kidney disease, and what factors are associated with its progression?
Cohort (n=70)
What is the natural progression of aortic pulse wave velocity over 12 months in patients with chronic kidney disease, and what factors are associated with its progression?
Mean Difference: 1.1
p-value: p=<.01
In patients with chronic kidney disease, arterial stiffness (measured by aPWV) progresses significantly by approximately 1 m/s per year, driven by age, systolic blood pressure, and diabetes rather than renal function decline.
aPWV progresses ~1 m/s/year in CKD; leaves open whether stiffness-targeted interventions alter CV outcomes.
Aortic pulse wave velocity (aPWV) is elevated in patients with chronic kidney disease (CKD) and predicts cardiovascular risk. However, the natural progression of arterial stiffness in these patients remains uncertain. Therefore, the main aim of this study was to investigate the development of aPWV and to identify potential factors associated with its progression. aPWV measurement was carried out in 70 CKD patients at baseline and after 12 months. Correlations to several variables, in particular annual glomerular filtration rate reduction and diabetes mellitus, were studied. In the cohort, aPWV significantly increased in 1 year by 1.1 m/s (P<.01). Dividing the group into patients with stable and progressive aPWV, factors associated with accelerated progression were age, systolic blood pressure, and diabetes, whereas loss of renal function had no significant impact. The annual aPWV progression in CKD patients reached 1 m/s, which predicts an increased cardiovascular risk. Variables involved with progressive arterial stiffness need further evaluation.
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Tholen et al. (2013) conducted a cohort in Chronic kidney disease (n=70). Chronic kidney disease was evaluated on Progression of aortic pulse wave velocity (aPWV) (1.1 m/s increase, p=<.01). Aortic pulse wave velocity in patients with chronic kidney disease significantly increased by 1.1 m/s over 1 year (P<.01), with accelerated progression associated with age, systolic blood pressure, and diabetes.
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