Key result
HCV core protein binds to the human DEAD box RNA helicase DBX and inhibits the in vitro translation of capped, but not uncapped, RNA.
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HCV core protein interacts with the host cell DEAD box RNA helicase DBX, suggesting a mechanism by which HCV inhibits host cell mRNA translation.
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Mamiya et al. (1999) studied Hepatitis C virus (HCV) infection. HCV core protein was evaluated on Binding to host cell proteins and effect on RNA translation. HCV core protein binds to the human DEAD box RNA helicase DBX and inhibits the in vitro translation of capped, but not uncapped, RNA.
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