Key result
A 4-kb renin 5'-flanking sequence fused to GFP directed multiple known renin expression patterns in transgenic mice, including in juxtaglomerular cells and developing renal vasculature.
Population
Transgenic mice carrying a reporter construct with 4-kb of renin 5'-flanking sequence fused to humanized…
Design
Preclinical
Authors
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No immediate clinical implications from mouse model; leaves open renin regulation mechanisms in humans.
A 4-kb renin 5'-flanking sequence fused to GFP serves as a useful vital reporter for tracking renin expression in vivo.
Jones et al. (2000) studied this question. renin/GFP transgene was evaluated on GFP expression patterns. A 4-kb renin 5'-flanking sequence fused to GFP directed multiple known renin expression patterns in transgenic mice, including in juxtaglomerular cells and developing renal vasculature.