Key result
Gene targeting in mice has demonstrated novel roles for the renin-angiotensin system in kidney structure development and the regulation of blood pressure and renal function.
Population
Mice with altered genes in the renin-angiotensin system (RAS)
Design
Review
Authors
Loading...
Gene targeting enables precise renal physiology studies in mice; leaves open translation to human disease until clinical validation.
Gene targeting provides a powerful approach for physiological investigation of the renin-angiotensin system and its role in hypertension.
Thomas M. Coffman (1998) conducted a review in Renin-angiotensin system physiology. Gene targeting using homologous recombination was evaluated. Gene targeting in mice has demonstrated novel roles for the renin-angiotensin system in kidney structure development and the regulation of blood pressure and renal function.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: