Key result
Jujube polysaccharides significantly ameliorated kidney function and hematological parameters in a CKD rat model, likely via regulation of short chain fatty acids release and erythropoietin production.
Why the study?
Jujube polysaccharides have been considered for the treatment of blood deficiency, but their effect and mechanism on chronic kidney disease-associated anemia required evaluation.
Does Jujube polysaccharides mitigate anemia in a rat model of chronic kidney disease?
Does Jujube polysaccharides mitigate anemia in a rat model of chronic kidney disease?
Jujube polysaccharides may mitigate CKD-associated anemia by regulating short chain fatty acid release and erythropoietin production.
Does not support clinical use in CKD; hypothesis-generating in rats and leaves open need for human trials.
Jujube polysaccharides (JP) is one of the active food sourced glycans in dietary fruit of Ziziphus jujuba, which has been considered for the treatment of blood deficiency. In this study, a chronic kidney disease (CKD) rat model was used to evaluate the effect of JP and its mechanism on CKD-associated anemia. In CKD rats, JP treatment significantly ameliorated kidney function, kidney pathological injury and hematological parameters, including increasing red blood cells, hemoglobin, hematocrit and platelet count. Moreover, LC-MS/MS targeted metabolomics results showed that JP promoted short chain fatty acids (SCFAs) release in CKD rats. Besides, JP alternated the serum erythropoietin (EPO) level, kidney EPO mRNA and kidney EPO protein via HIF-α signaling. Collectively, these results provide evidence that the effect of JP on CKD-associated anemia may be involved in regulation of SCFAs release and erythropoietin production, supporting further development of JP as food supplements in treating CKD-associated anemia.
No takes yet. Share an insight, caveat, or question.
Huang et al. (2021) studied CKD-associated anemia. Jujube polysaccharides (JP) was evaluated on Kidney function, kidney pathological injury, and hematological parameters. Jujube polysaccharides significantly ameliorated kidney function and hematological parameters in a CKD rat model, likely via regulation of short chain fatty acids release and erythropoietin production.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: