Key result
Asthma and chronic bronchitis were associated with a lower sputum MMP-9/TIMP-1 molar ratio compared to controls, which positively correlated with FEV1 values.
Why the study?
Is airflow limitation in asthma and chronic bronchitis associated with an imbalance between MMP-9 and TIMP-1?
Observational (n=57)
Is airflow limitation in asthma and chronic bronchitis associated with an imbalance between MMP-9 and TIMP-1?
Airway inflammation in asthma and chronic bronchitis is associated with an imbalance between MMP-9 and TIMP-1, which correlates with airflow obstruction.
No takes yet. Share an insight, caveat, or question.
Similar MMP profiles limit diagnostic distinction in airway disease; leaves open differential TIMP roles in remodeling.
VIGNOLA et al. (1998) conducted an observational in Asthma and chronic bronchitis (n=57). Asthma and chronic bronchitis vs. Control subjects was evaluated on MMP-9 and TIMP-1 concentrations and their molar ratio in induced sputum. Asthma and chronic bronchitis were associated with a lower sputum MMP-9/TIMP-1 molar ratio compared to controls, which positively correlated with FEV1 values.
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