Key result
Estrogen replacement and acute premarin infusion significantly attenuated exaggerated blood pressure responses to mental stress and norepinephrine-induced vasoconstriction in postmenopausal women (P<0.001).
Why the study?
Does estrogen attenuate abnormal norepinephrine-induced vasoconstriction and exaggerated blood pressure responses to mental stress in postmenopausal women?
Population
53 healthy, normotensive women with normal lipid profiles, comprising 18 premenopausal, 22 postmenopausal…
Comparison
Acute infusion of Premarin 200 microg/min… vs Norepinephrine infusion alone; premenopausal…
Design
Cross-sectional
Authors
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Estrogen may attenuate exaggerated stress BP responses via reduced vasoconstriction; leaves open causal effects pending randomized trials.
Does estrogen attenuate abnormal norepinephrine-induced vasoconstriction and exaggerated blood pressure responses to mental stress in postmenopausal women?
p-value: p=< 0.001
Estrogen administration acutely attenuates exaggerated norepinephrine-induced vasoconstriction in postmenopausal women, providing a physiological mechanism for the increased blood pressure response to stress following menopause.
Sung et al. (1999) studied Healthy, normotensive postmenopausal women (n=53). Estrogen (replacement therapy and acute Premarin infusion) vs. Postmenopausal women without estrogen was evaluated on Hemodynamic responses to mental stress and constrictor responses to norepinephrine (p=< 0.001). Estrogen replacement and acute premarin infusion significantly attenuated exaggerated blood pressure responses to mental stress and norepinephrine-induced vasoconstriction in postmenopausal women (P<0.001).
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