Key result
Buyang Huanwu decoction (18 g/kg/day) alleviated ventricular remodeling in a rat model of myocardial infarction by decreasing the apoptotic index and affecting multiple protein targets.
Why the study?
Does Buyang Huanwu decoction alleviate ventricular remodeling in a rat model of myocardial infarction?
Population
Rat model of myocardial infarction induced by left anterior descending (LAD) artery ligation
Comparison
Buyang Huanwu decoction (BYHWD) 18 g/kg/day vs Model group (untreated LAD ligation rats)
Design
Preclinical
Follow-up
12 weeks
Authors
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Should not change clinical practice; hypothesis-generating for BYHWD in post-MI remodeling.
Does Buyang Huanwu decoction alleviate ventricular remodeling in a rat model of myocardial infarction?
Buyang Huanwu decoction alleviates ventricular remodeling and apoptosis in a rat model of myocardial infarction, potentially via upregulation of PRDX6 and HSPB6 phosphorylation.
Zhou et al. (2012) studied Myocardial infarction (ventricular remodeling). Buyang Huanwu decoction (BYHWD) vs. Model group was evaluated on Ventricular remodeling (HW/BW, LVDd, LVEF, LVFS, collagen volume). Buyang Huanwu decoction (18 g/kg/day) alleviated ventricular remodeling in a rat model of myocardial infarction by decreasing the apoptotic index and affecting multiple protein targets.
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