Key result
Genetically engineered animal models demonstrate the significant in vivo roles of the natriuretic peptide system in cardiovascular, renal, and skeletal homeostasis.
Genetically engineered animal models demonstrate the critical role of the natriuretic peptide system in cardiovascular, renal, and skeletal homeostasis.
Preclinical models highlight therapeutic potential; leaves open translation to human cardiovascular and renal disease management.
The mammalian natriuretic peptide system, consisting of at least three ligands and three receptors, plays critical roles in health and disease. Examination of genetically engineered animal models has suggested the significance of the natriuretic peptide system in cardiovascular, renal and skeletal homeostasis. The present review focuses on the in vivo roles of the natriuretic peptide system as demonstrated in transgenic and knockout animal models.
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Kishimoto et al. (2011) conducted a review in Cardiovascular, renal and skeletal homeostasis. Genetically engineered animal models was evaluated. Genetically engineered animal models demonstrate the significant in vivo roles of the natriuretic peptide system in cardiovascular, renal, and skeletal homeostasis.
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