Key result
Natriuretic peptide receptors A and C were expressed more strongly in the atria than the ventricles of healthy dogs and cats, while receptor B was largely undetected.
This preclinical study maps the distribution of natriuretic peptide receptors in canine and feline hearts, demonstrating regional variations that align with the distribution of their respective ligands.
Species-specific NPR mapping in healthy canine/feline hearts is hypothesis-generating; leaves open translation to veterinary or human natriuretic peptide therapies.
We examined the immunohistochemical distributions of natriuretic peptide receptor (NPR)-A, -B and -C that bind with natriuretic peptide hormones A, B and C in four healthy crossbreed young canine and feline cardiac tissues using specific antibodies against human antigens. Cross-immunoreactivities between antigens and antibodies were confirmed using western blot analysis. NPR-A and -C were expressed more strongly in dogs than cats. In both species, these expressions were stronger in the atria than the ventricles, with stronger expression in the left ventricles than the right. NPR-B was largely very weekly or undetected. In canine and feline cardiac tissues, the expressional distribution of NPR-A, -B, and -C closely matched with that of atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide as the ligands for corresponding receptors.
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Yamane et al. (2010) studied Healthy (n=10). Immunohistochemical staining for NPR-A, -B, and -C was evaluated on Distribution of natriuretic peptide receptors (NPR-A, -B, -C) in cardiac tissues. Natriuretic peptide receptors A and C were expressed more strongly in the atria than the ventricles of healthy dogs and cats, while receptor B was largely undetected.
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