Key result
Compared with nulliparity, grand multiparity (≥5 live births) was associated with 11% higher resistin levels and 3-4 live births with 23% higher leptin levels, though attenuated by CVD risk factors.
Why the study?
Multiparity is a risk factor for CVD, but the mechanisms underlying this relationship remain unknown, and adipokines may predispose multiparous women to cardiometabolic complications.
Is multiparity associated with altered adipokine levels in women free of cardiovascular disease?
Cross-Sectional (n=973)
Yes
Is multiparity associated with altered adipokine levels in women free of cardiovascular disease?
Effect estimate: 11% higher (95% CI 0-23)
Greater parity is associated with higher resistin and leptin levels, but this association is attenuated by traditional CVD risk factors, suggesting adipokine dysregulation may play a complex role in multiparity-associated CVD risk.
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Multiparity linked to adverse adipokine profile; leaves open whether these changes mediate excess CVD risk, needing prospective confirmation.
Rodriguez et al. (2021) conducted a cross-sectional in Cardiovascular Disease Risk (Adipokine Dysregulation) (n=973). Multiparity vs. Nulliparity was evaluated on Resistin levels (percent difference for ≥5 live births vs nulliparity) (11% higher, 95% CI 0-23). Compared with nulliparity, grand multiparity (≥5 live births) was associated with 11% higher resistin levels and 3-4 live births with 23% higher leptin levels, though attenuated by CVD risk factors.
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